منابع مشابه
Developmental changes in proteoglycans of rabbit corneal stroma.
Proteoglycans have been extracted from rabbit corneal stromas at developmental stages from fetal to adult. Ion exchange fractionation and gel chromatography show that proteodermatan sulfates decrease in sulfation and relative amount and proteokeratan sulfates increase in sulfation and relative amount during development. There are small increases in size of all of the proteoglycans up to 2 weeks...
متن کاملGenomic alterations in tumor stroma.
It was traditionally believed that the tumor was the seed that lay in the passive soil of the microenvironment, with the latter providing "permissive elements" for the tumor to grow and invade. Subsequently, it was recognized that both neoplasia and its microenvironment interacted as equal partners. Recent advances addressing genomic alterations in the tumor microenvironment, relevant to clinic...
متن کاملCharacterization of the keratan sulphate proteoglycans from bovine corneal stroma.
The keratan sulphate proteoglycans that can be prepared from bovine corneal stroma [Axelsson & Heinegård (1975) Biochem. J. 145, 491-500] were characterized by gel chromatography, gel electrophoresis and analytical ultracentrifugation in associative (0.6 M-NaCl) and dissociative (6M-guanidinum chloride) solvents. The proteoglycans aggreagated at low salt concentrations and pH. The weight-averag...
متن کاملTumor-stroma relationships
Cancer is characterized by somatic mutations that provide a growth and survival advantage. The mutations are a function of chance because of the random nature of mutagenesis. However, the biology in the tumor cells drives the selection of mutations that are advantageous to the cancer. 1 in addition, the tumor environment exerts a selective pressure on the tumor. For example, the hypoxic environ...
متن کاملGangliosides shed by tumor cells enhance tumor formation in mice.
The role of tumor cell membrane gangliosides in tumor formation was probed using a series of cloned murine AKR lymphoma cell lines. Tumor formation was directly related to high expression and shedding of membrane gangliosides. In vivo, as little as 1 pmol of purified total gangliosides of highly tumorigenic cells, injected intradermally with poorly tumorigenic cells (which lacked and did not sh...
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ژورنال
عنوان ژورنال: Cell and Tissue Research
سال: 2016
ISSN: 0302-766X,1432-0878
DOI: 10.1007/s00441-016-2452-4